Mouse buttons non functional after 5 or 10 minutes.

This past couple of days I've been reformatting and re-installing windows and tweaking my partition sizes. However, yesterday evening, after finishing loading up Windows XP and in the middle of loading my programs my mouse buttons just stopped working for no apparent reason.
The cursor movement works just fine but the buttons are non responsive.
I reformated and reinstalled windows again this morning thinking everything will be fine but low and behold during my program load up the buttons packed up again after about 5 or 10 minutes.
Any ideas?
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