ATI overdrive in the CCC will not be available unless you have a specific 8 pin PCI-E connector (usually found on higher end DX10 compatible PSU's). You might be able to find an adapter of sorts but what really should be used is a compatible PSU of higher grade. As for OCing with 2x6 PIN's, you may have luck using ATI Tool or ATI Tray tools but do so at your own risk. My HD2900XT did not like being powered by just the 2x6 pins. She would screetch like a siren when loaded. I bought an Enermax Liberty 620WT specifically for its 8-Pin PCI-E.
And for the love of god, please do not attempt to plug in your 8-Pin MB plug from your PSU unless you really like the smell of burnt PSU's.
Ohh, and if you had not realized, you will need both 1x6-Pin and 1x8-Pin, not just the 8-Pin, both. She is a hungry VGA.