This may sound a little bit oddball, but seeing that the Asus board is larger than the standard ATX spec has got me thinking - top end motherboards trying to pack every feature in should move to E-ATX format, similar to server boards.
Yes, the old BP6 was a dual socket ATX board, but it had no way near the features of todays boards and it didn't push the amps that these X38 boards use.
The upcoming Skulltrail and 4x4 are both dual CPU designs, making room for two CPU's plus all other regular mobo features AND allowing 2 or 4 dual-slot video cards to fit cannot, IMHO, go without some sort of redesign in either mobo layout or case size. I know EATX won't give any extra slots above 7, but it could allow mobo makers to play around with CPU, NB and ram slot placement.
I'm not suggesting that ATX be dumped or replaced overnight, but it is becoming ever more evident that increasing feature sets and multi-GPU requirements have reached the size limits of what an ATX board can physically accommodate.