Not sure what you mean by set up. Building is just installing the components and installing Windows or what ever OS you're using and the programs. Really just follow the directions in the manual that'll come with the mobo. The biggest challenge is choosing the right parts for your budget and how you'll use the machine. If you have questions regarding parts, best to post in the New Build section and include your budget and how you'll use the machine. If you've chosen the parts, list them