First question: no, unless you had some smoke or sparks. Second question: not likely the cpu is the problem, unless you lined it up wrong on the socket. You can do the following with or without the cpu and you'll get some beep codes if you have a case speaker connected to the board. Take the board out of the case and place on a cardboard surface, such as a phonebook or box the board came in. Connect the main 24 pin power supply atx connector, the 4 (or 8) pin 12v ps connector, use only one stick of memory, (cpu/heatsink), video card with monitor connected. Locate the case connector pins. All you have to do is touch the 2 power switch pins with a screwdriver and the system will power up. With the case speaker connected, you'll get beep codes, which will id your problem. If your case doesn't have a speaker, you can buy bare small speakers at radio shack and probably jury rig one for your case. Connecting external speakers to your sound port on the back of the board won't give you beep codes. Good luck. The asus striker extreme should work right of the box with the q6600. I just noticed that the striker has 4 of the 8 pins covered for the 12v lead. Means that you can use an older ps with just the 4 pin 12v connector if your power supply doesn't have the 8 pin connector. Two last thoughts: be sure your memory stick is seated in the slot. If seated (installed) correctly, you should hear 2 clicks when pressing down as the outer tabs lock it down. And be sure the power supply lead is connected to the video card, if required.