If you want to do SLI, it's OK.
When running SLI, each slot is only 8x, which will limit high end cards slightly. It will greatly restrict new high end cards that will come out shortly. The limit on say an 8800GT should be minimal in SLI.
The 650i also will definitately not support QuadCore Penrny.
Possible Dual Core Penryn, be sure to check.
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