newb question: Overclocking CPU without touching dram

I have 2x2gb PC 8500 DDR@ sticks (1066 MHz)

Can I OC my E8500 (333*9.5) to say 400*9.5 (ie. 3.8 GHz) without touching my DRAM settings? Since my memory is 1066 MHz I have plenty of room and the memory should handle it fine in a 1:1 setup? (400*8 = 800 MHz and my mem supports 1066 MHz)

In this scenario, all I have to do is make sure my memory settings/Tmings are set correctly to manufacturer (I have the CORSAIR DOMINATOR 4GB (2 x 2GB) 240-Pin DDR2 SDRAM DDR2 1066 (PC2 8500) Manufacturer tested at 5-5-5-15 2T at 2.1 v 1066 MHz)

If that is correct, and if I wanted to mess with the DRAM to get tighter timings, then would it make sense to lower the timings to see how things play?

Thanks