E-SATA is the fastest and USB is the most versatile. With Vista you can Hot swap an external SATA (E-SATA) HDD. USB is just about 100% universal. Meaning you can take your HDD with you and axcess the data on the HDD from almost any computer.
My choice is An external HDD that has E-SATA and USB.
Large 3.5in external drives that are used in desktops all use power supply's. Smaller and slower laptop 2.5in drives are usually powered over the USB port if you have USB 2.0. Laptops drives are more expensive per gig.
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