I have an Asus P5E board...currently the only slot I have for x16 is the lower one (For the 3780X2 dual slot to clear). Now...can I install my card in the lower slot and not have any performance degradation? I'm thinking I'll be fine...but always helps to have other opinions. I can't shuffle any slots around because of some studio hardware using all the x1 slots. The only exception to the rule would be removing the FX sound card from the upper x1 slot and relocating the studio card from under the upper x16 slot to it's location to provide room for the dual slot config on the that x16 slot. This would only happen if I knew that the SPDIF and/or Optical out would still output audio if the card was removed. Sounds confusing...but just really want to know if the lower x16 will be fine...might have to play with some IRQ's but hope it's fine. Any help would be greatly appreciated