Nope. The power connector, while physically the same, is hooked up differently. The desktop drive uses a combination of 3.3V, 5V, and 12V, while a notebook drive doesn't use the 12V, relying entirely on the 3.3V and 5V. The connector is the same for compatibility reasons (you can hook a notebook SATA drive straight to a desktop connector and it will work fine), but a desktop drive will not work in a notebook due to the lack of a 12V feed from the notebook.