On the timings - Tighter is more responsive. But the differences between the two (cas 3/4 and cas 4) are small. I would buy the 2 x 2 kit.
--------------- The more I read the forums, the more I feel that a number of individuals would be well served by skipping their next GPU purchase in favor of a little "Stress relief" from the local 'Working Girls'"
I would rather have 4GB over tighter timings but why not have both? The dominator timings are nice but Vista likes ram even with 32bit 4gigs will show improvement.