Yes, depending on your motherboard. If theres the option to run both onboard and pci in the bios then yes. I have an ECS black edition 8200A that allows me to - At the moment I am running both the onboard Nvidia 8200 and a Radeon HD 6870 PCI E video cards problem free. You must instal display drivers for both and enable the option to "both" in your bios.