USB mouse problems in Vista

My mouse will only work on certain areas within Vista. I can open tabs in Firefox but tabs within Yahoo mail for instance cannot be opened. It also does not allow some areas in other applications to be selected.
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  1. To help us assist you, please provide more information:

    1) Decribe the issue you are having in detail. For example if its with a specific piece of equipment, include the make and model.
    2) When was it last working normally? Since then, did you add/remove any software or hardware?
    3) What steps have you already tried to resolve the problem? (rebooted, searched google, etc)
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