Aside from the whopping prices ($1,500 for a 450GB SSD?!?) and the need to use up valuable expansion space, are there any other issues that make PCIe-based SSDs incompatible for the prosumer/enthusiast market?
(It would be nice to have a 450GB SSD though, I can only imagine how fast loading times would be!)
Sure, maybe in a few years most PCs ship with a small PCI-express card with flash chips, instead of a SATA-connected SSD. What is 300MB/s if you can have 8000MB/s bandwidth? Even better, this bandwidth is full-duplex!
The only real issue is that you need a driver, and you need "interrupt 19 capture" BIOS-support. Also note that operating systems like Windows and applications running on Windows, are not designed with working with parallel storage media like SSDs. The operating system is optimizing the I/O to be more contiguous, but this only hurts performance for modern SSDs.