Hard drive error??

Hi,
I'm getting this error when I'm trying to uninstall a PC game (rome: total war) and when I'm trying to update another game (Call of duty 4 from 1.0 to 1.6). The error reads: "There is not enough free space to perform the requested operation. Please free up some space and try again."

I know for sure that space is not an issue, for I have 100's of free GB on my hard drive and especially when I'm trying to uninstall a game. I've tried to Google the error but I came up with nothing. I'm guessing maybe there's something wrong with windows install shield wizard, but I was able to uninstall and re-install COD4 without having any problems; however the problem only occurs when I try to apply the patch. Any help will be appreciated. Thanks.

Yes, I do have two hard drive in my system. In fact, I just recently bought a TB hard drive and I'm trying to reinstall COD4 to that hard drive. After several attempts and failures of trying to update it, I then decided to uninstall it from my new drive and install it on my C drive, the one that as my OS and it had the same problem. Both hard drives have enough space for the game. I'm really at a loss here.

For what it is worth,, the only time[s] that I ever see that message is when i am trying to install something on a non NTFS partition ,it usually means that the partition is 32bit fat and will not take a file bigger than 4g..