No problems likely, but when paired up the 4 DIMMs may not run at CAS 2 LAT. You may need to use 2.5 or even 3 CAS. 4 DIMMs will call for 2T and possibly an increae in memory voltage to something like 2.6-2.7v. I have the MB for many years and currently use 2 x 1 GB OCZ Platinum PC3200 with VISTA 32. I have used all kinds of RAM over the years.