You can't remove the region setting for your DVD drive, but you can change it up to a maximum of four changes - after which it can't be changed any more.
Control Panel > Device Manager
Double-click your DVD drive name.
Click the "DVD Region" tab.
To play DVDs purchased in the UK:
Scroll down to "United Kingdom" and click it once (left-click). Region 2 should appear in the "New Region" box.
Click 'OK'