i didnt know there was a 65nm 4600+. well anyway the only way for you to decide is going to be based on which features you want in a motherboard. my cpu decision was made over the motherboard. amd's 780G chipset offered a lot of features and has half-decent integrated graphics. that may not be of any use to you though. What I especially liked about the board i picked up was that it has a pci-e 2.0 slot, which is very nice to find on a $70 board. it was also one of the only boards i could find with 8.1 channel surround sound support onboard. this was important to me because i wanted my speakers to work fully. either way your games will run fine, it just depends on if you plan on overclocking, and what your needs in a mobo are. also, the resolution you game at can make a difference here. if you're gaming at high resolutions, get a cheaper cpu and a more expensive video card.