Load Line Calibration reduces or removes the drop in voltage that occurs under load that can destabilise an overclock. There are reasons why you might want to leave it disabled but I don't know if those reasons outweigh the benefits of enabling it. By the way, don't disable thermal control unless that's just to do with fan speeds. There is absolutely no reason why you'd want to disable your CPUs ability to protect itself from overheating.
Message edited by randomizer on 07-25-2009 at 01:54:54 PM