1) Nope. The drivers should take care of everything.
2) By default, the game will run full screen on your primary monitor (the one with the start menu and taskbar). Some games do support multi monitor though (like FSX), and you can do certain tweaks to make more use of both monitors. Alternatively (this is what I like to do), you can put temperature and usage monitors on your secondary monitor, so at any time you can see how much your CPU/GPU is being used (see what the limiting factor is), and how warm they are getting.