This board doesn't support Crossfire since it only has 1 PCI x16 slot. You need two x16 slots to have crossfire. By crossfire I mean 2 separate cards. Good crossfire boards are the ones with an X48 chipset. P45 chipsets also support crossfire but the two x16 slots run at x8 speeds but on the x48 chipset, both slots are x16. If you have the extra cash, get the x48.