I currently use my HDTV as my main display. As long as you don't do any intense professional graphical editing, you'll be mostly fine. I hope that you plan to sit a bit away from the screen, because HDTVs output a lot more heat than an LCD monitor outputs.
As far as setting it up is concerned, you really shouldn't have any problem. Just make sure you can set it up to where you can sit comfortably away from it.