What do you mean by fit?
If you mean PCI-E, the motherboard supports it so the videocard will "fit".
If you mean physical obstruction, unless you have a PCI-E x1 card right below the PCI-E x16 slot, the video card will "fit".
Most importantly, you want to make sure the video card will fit in your case. Make sure you have adequate space, since this card is huge. It's about as long as the motherboard it sits on.