If it was there when the spreader and CPU were first put together, it'll probably stay there, maybe crushed. If the spreader and CPU weren't correctly assembled, with, say, one corner not having adequate pressure, maybe. If you have taken the spreader and CPU apart, maybe.
Even if you have used too much thermal compound, the excess should have just squeezed out at assembly time.
Otherwise, I would say no, as the pressure will be too much for most things to get in. The only exception I can think of is you've soaked one side of the heat spreader in, e.g., some kind of acid that dissolves the heat spreader material - that would leave a gap that could allow something in, although you'd probably be worrying about bigger problems (like where did the acid come from? what other damage did it do?).