Make sure your power supply can support it:
ATI Radeon HD 4850 System Requirements
450 Watt or greater power supply with 75 Watt 6-pin PCI Express® power connector recommended (550 Watt and two 6-pin connectors for ATI CrossFireX™ technology in dual mode)
Certified power supplies are recommended. Refer to
http://ati.amd.com/certifiedPSU for a list of Certified products.