2x2gb is preferred. 1.8v if you can that is the standard voltage. but 2x2 is only using 2 slots then. less chance for problems and 2 open slots if you decide to add more later. if you get big into 3d stuff you may want to add 4 more gb at a later date.
that is a nice resolution monitor. you will be able tax most gpu's with that resolution. thing is that 1 4870x2 performs better than 2 4870s crossfired. So if you can afford it i would do that.
your psu is going to be determinate on what card(s) you end up with. if you stick with the x48 and are going to do 2 cards you are going to need more than if you do one card on the p45
Assuming you are using a good psu here is the breakdown:
500w ok for
1 4850
1 4870
650w ok for
1 4870x2
750w ok for
2 x 4870
around 1000w or a little less for:
2 x 4870x2
i tend to error on the side of more than you need so others may be able to get you a little closer to true minimum wattage.
So figure out your budget. then figure out what you can afford GPU. Then decide if you are going to add another of the same down the road. but it would have to be relatively soon because if it is going to be a year or more there will be much better single cards at that point probably. once you decide if you are going to get 2 cards relatively soon then that will help you on x48 or p45. p45 can do two cards but at your nice resolution x8/x8 will have some impact. if you resolution was lower i would say get p45 no matter what because at lower resolutions x8/x8 has virtually no impact.
hope i've given you enough to think about .