The reasons I am setting it up as updraft is because the case has far better updraft capability (2 fans) vs the one in the back. I already am considering an Graphics Card intake, which is mentioned in the OP. I appreciate the Occam's razor however.
Well then think of it this way: The updraft will go across the front of your CPU cooler if you crossdraft the cooler. That is to say, the cool air flowing upward will cross the CPU cooler's intake fan if you set the CPU cooler in a crossdraft configuration. Crossdraft FTW!