No, it doesn't seem to. I turn off C1E and EIST until I get a stable OC, then I turn them back on. I haven't had any problems.
I suspect that a debate on this topic would have the same results as one about leaving your system on 24/7 or turning it off when you're done with it - that is, inconclusive. I have two that run 24/7 and one I turn off.
OTOH, I do not pay my utility bill in Saudi Arabia. My company does.