CPU socket placement is just like any other.
All 750i motherboards only support 4 SATA ports, this is a limitation Nvidia designed on the 750i chipset.
NB heatsink is huge because it also cools the NF200 chip, which provides the 16x 16x SLI capabilities. Using the provided NB fan, I've never had any problems with the NB cooler.
NB cooler will not interfere with any video card. I've used 8800GTX, 9600GT, and now GTX260 and never had any problems with the 1st PCIe slot.
What runs hot? NB, CPU, memory?
Vdrop is .04v on avg. This can be eliminated with pencil mod if you are inclined to do so.
This board is not perfect, but complaining about board layout is just dumb. You have plenty of choices to view the layout, before you make the purchase. If I could chose again, I would take EVGA 750i FTW instead. However you are looking at a $30 - $40 difference.