It's better to use smaller fans to add direction to the airflow than to use a big fan and put air everywhere and mess up the airflow you have already in the case.
Remember heat rises, use that to your advantage.
It doesn't matter so much as the amount of air your pushing as long as it has good direction, the sooner the air goes where it needs to and gets out the better. Putting alot of air in random directions may end up being counter production, as it may circulate around the case and linger for awhile before getting sucked out.
Take a look at cases that are well known for good air circulation and build off those ideas. Antec 900/1200, CM 690, HAF 932, just a few I can list off memory.