I beleive what you are thinking of is called "drive scaling."
I read an article (online) that had 4 HDD in a RAID 0 array, and it was faster than an SSD. But they knew what to do, and I don't remember the name,type,size,gen of the SSD. I do know they had 4 small, fast HDD.
Why would you want such a large size SSD? 80GB should be good, for an OS, and Program Files drive. Now, if you have A LOT of Games, maybe more?
The trend these days is to get a SSD for just OS and Program Files (Office, etc.), and put all your "data & media" on a second HDD. The more use write to a SSD, the more "damaged" it becomes, but this is a whole other forum.
1-Intel X25-M 80GB is well enough. 2-in RAID 0 will rock! I have 2-Intel X25-V 40GB in RAID 0, and after much communication within THG, I happy with my set up. I do loose some special features of SSD (TRIM), but there is a whole other post for that.
Anyway RAID 0 is the "fastest" array. But tread lightly, if you don't know about RAID arrays. Do some research. Lots is in here!
BTW: Most modern motherboards support RAID. A hardware RAID within the board is (usually) better than a software RAID. Else, there are add-on cards (PCIe) that support RAID. Even SATA III, 6.0Gbps. Yet a whole other post.