What is wrong with windows when the programs wont open

Hello,
I have friend that is having a problem with windows. He said that windows will come up but none of the programs will open. Can anyone help with this program?
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More about what wrong windows programs wont open
  1. you will need to provide more details that that...

    one thing I can say, could be a virus. Could also be a million other things...
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Windows XP