I am replacing everything in my current computer with the exception of the cpu, gpu, psu, and case. The Hardrive, DvD drive, Motherboard, and memory are being replaced. This is mainly due to my motherboard not performing to specifications, it cannot run ram at ddr2 800 speeds even though it says it supports it.
Are my chances good at successfully reactivating my Vista 64bit oem onto this basically new machine?
You can try to reuse the same serial, but chances are that it won't work because it will be too different.
So you will have to call microsoft and say you are upgrading your pc and need a new serial key. If they say upgrading is not good for OEM, recall after an hour and say your mobo fried and needed to be replaced.