you know when people say that cards can be overkill say if you did get a gtx 295 and only ran on a low resolution, if you've got the money and you want to spend it why not? surly it just means you will get Much better fps and performance?
Two 9800GTX+ beat a single GTX280. Also, SLI'ing GTX260's on a 22" is a little too much. You will do alot better with a single GTX280 or SLI'ing 9800GTX+. I vote for a single GTX280 to eliminate any potential SLI issues like no support/poor scailing.