in the comparison of the 4850 X2 and 280 or 285 GTX, for me isn't a choice. I would much rather have a slightly slower single GPU, then dual weak gpus, if the extra gain is sometimes nill. Thats my 2 cents on the situation. The thing is that the 285 GTX can be 100$+ more than the 4850 X2. Which can be a problem. And the 4850 X2 is a Sapphire exclusive, which doesn't raise my confidence in the card either.
If it were me, I would bite the bullet and grab a 285 GTX...but at your resolution I would also look into the 260 GTX or 4870. I mean the 285 GTX can be overkill for that resolution...only game that you can't say overkill in is Crysis. The most of the rest can be handled by a 8800 GT
But like I said, even the 285 GTx can be pushed to its limits at that low resolution (just like any card) if the game is just ridiculously demanding. Also I want to add that for the 4850 X2 to work, the game needs to scale, so its alot more driver dependent than the 285 GTX or any other single gpu
The 4850 X2 and 280 GTX are basically on par from benchmarks I've seen, with the 4850 X2 slightly edging it out in most benchies, and the 285 GTX is generally 10% faster.
But I've been rambling whats your specs.... I mean all of this can be ignored if you don't have the hardware