Password on portable drive

I have couple of portable drives that have software and such on them. Is there a way too put certain rights on the drive so that people cannot edit or delete it with out those correct permissions. More so AV because one i plug my drive into a computer that running symmatec all key gens and scripts such get picked up
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  1. Yes, you can put permissions on specific folders and programs on flash drives.

    Here is a suite that you can put on a flash drive that has a multitude of apps.
    You don't need the suite but this is an example.

    http://portableapps.com/

    Here is a great portable anti-virus you can install on a flash drive.
    http://portableapps.com/apps/utilities/clamwin_portable

    You can't really hide things from an AV unless you encrypt the drive.

    If you want to Encrypt the drive you can use.
    http://www.truecrypt.org/
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