No. If you buy a retail version (not OEM), it should included the brackets to mount the 2.5" drive into a 3.5" bay. Else, get a "Hot Swap Bay" or "Mobile Rack." It got this one
, but it's a dual drive set up. But you can use only one bay.
My case is great, if you don't get a huge graphics card with that many drives. Less than 9.5", 'cause the card can be too big, and run into the hard drives.
Look at THG SBM here
, where they used a Antec 300, and 2 graphics cards. Note the cards and the drive, cramping each other.
Yes, the case in an Antec 300 Illusion, but the same size as a regular 300. The Illusion includes blue LED fans, the only difference.