Most sound cards are still PCI. As long as you have an open PCI slot it will work. Some newer cards use PCI Express x1 and you'll either need an open PCI Express x1 (The shortest in physical length of the PCI Express line), PCIe x4 (Little longer), PCIe x8 (Same length as a PCIe x16 video card slot jsut runs at lower electricity), or a PCIe x16 slot (Newest video card slot.) Each will work but if you go with something longer than x1 it will just run at the lower electric rate... no performance will be lost or gained though. I have put a sound card into a PCIe x16 lane before to test it out and it worked fine.