2) I dont know
3) Depending on your OS (Vista and 7) enable it by default as far as I am aware and you have to manually disable it.
4) I would think windows does that automatically but I am not sure
5) The pagefile should be removed from the SSD onto one of the SATA drives
6) Indexing and Superfetching should be disabled as they will wear down the SSD faster.
Sorry I dont know the answers to all of your questions.
What operating system as Trim is only supported with win 7 and since you mentioned Trim I' assume that is what you are using.
(1) and (2) If HDDs are not part of a raid configuration, you can use AHCI for SSDs and HDDs. If planning on using raid0 or Raid1 for the HDDs then I recommend putting them on seperate controllers. On my I5-750, I have a SSD and 2 HDDs on the Intel controller set to AHCI, and I set my Blu-ray writer and DVD writer to GSATA Controller (Have gigabyte MB).
(3 and 4). Windows 7 will (1) correctly align partition size (you can verify, just google check Patition size. (2) Windows 7 installation should atomatically disable defrag and enable trim support.
(5) On page file - pros and cons. On my two laptops (they only support 1 HDD and they each have 4 Gigs of RAM) I set the page file min and max value to 1 Gig (win 7 does not like 0). This tends to reduce dynamically varinging the size, reducing read/writes. On my desktop (80 Gig drive SSD), I set the swap file to the HDD (D Drive) and set the min and max values to the "Recommended" size - 1.5 x memory, 6 gigs and for a 64 Gig SSD with 4 gigs of ram that equals 10 % of the SSD space.
(6) Myself, I disabled indexing and superfetching, Also disabled hibernation. Not a biggy as read/write cyles with these enabled should not decrease lifetime by a great amount, unless you do allot of read/writes. While the performance may be sligthly better with these enable, Disabling these MAY improve performance inbetween Trim Cmd as trim is not a constant running cmd but only implimented when certain conditions are meet. And if "life" is a question, may sleep easier if Disabled.