If you're system's 100% stable with them enabled I see no problem with them. My Q6600 was fine at 3.2GHz with EIST enables, but it's disabled at 3.6GHz
I routinely run my e8400 at 4 GHz with speedstep off. It'll boot okay with EIST enabled but I'll get crashes on 3DMark06. However, with EIST off I can run the benchmark all the way as many times as I have time for.
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