How do I delete registry setting when the computer wont let me

I have Vista Antispyway virus. I went through and deleted all registry files related to the virus and have 3 left to go. Everytime I try to delete them, I am told I can not. How do I delete them?
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More about delete registry setting computer wont

  1. You need to change the Permissions of the hives or keys concerned. Right click then go to Permissions and take Full Control or click Advanced and take Ownership. Why didn't you let MalwareBytes do all this in Safe Mode?

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