The first thing to try is, with the power off at the rear switch, to jumper the CLR_CMOS pins in the center of the board for a few seconds, remove the jumper, then power up the machine and enter the BIOS (if you get a graphics 'splash csreen, you will need to depress <TAB> to get to the post screen) from the POST screen by depressing <DEL>, cursor to the "Load Optimized Defaults" item, and depress <ENTER> to execute this function; save and exit for a reboot, and, with any luck, problem will cease...
Another thing to be aware of is that, if you have Seagate drives, there are a large number with a firmware problem that will sometimes prevent them from coming on-line, and look like a 'dead' drive:
http://seagate.custkb.com/seagate/crm/selfservice/search.jsp?DocId=207931
Follow their directions carefully; 'flashing' the repair firmware to certain drives which do
not require it will render those drives inoperable!