Any SATA HDD should work just fine on a mobo with SATA 6.0 Gb/s ports. BUT do NOT expect it to work faster because of that! In fact, very few SATA drives of the mechanical types (spinning disks and moving heads) can even get their average data transfer rate over the 1.5 Gb/s communication max of the original SATA specs. The only devices that actually can take advantage of the SATA 6.0 Gb/s spec are the SSD's. So some people will connect their SATA HDD's to older-spec SATA 3.0 Gb/s ports on the mobo, and leave the 6.0 new ports free for future use with really fast devices.