you could but it would require soft raid to be economical. In a Windows system this requires 7 Pro/Ult in Linux you can use LVM.
The scenario I see is that you want redundancy to boot the system in the event the SSD fails, but gain the performance benefits while it functions. - Using RAID 1 (mirror: Read from many, write and wait for all data to be written to each disk independently)
You can partition the disk to -160M (GBx1024 - 160 =MB) the size of the SSD for a system disk. Convert both the boot volume and SSD to dynamic and create a raid mirror. This will decrease the read cost (read from both) but increase the write cost (write-wait, write-acknowlege). Since its SSD there should be no noticeable write degradation. The rest of the disk can be mech-only and used for archives. Gaming, multimedia, etc all are read-intensive. There is really no demand for write performance unless you are transcoding blu ray movies or housing a database that is actively used.
It'll work great, go for it. I've been considering a cheap 32G SSD for my laptop for just that purpose.