Most motherboards will allow you to mix memory sizes, as long as you keep the corresponding DIMMs in each memory channel the same size. For example if you have a motherboard with a two-channel memory controller, you could have two 4GB DIMMs and 2GB DIMMs, but not 1 of one type and 3 of the other.
But it does vary by motherboard, so you really need to consult your manual.
Most motherboards will allow you to mix memory sizes, as long as you keep the corresponding DIMMs in each memory channel the same size. For example if you have a motherboard with a two-channel memory controller, you could have two 4GB DIMMs and 2GB DIMMs, but not 1 of one type and 3 of the other.
But it does vary by motherboard, so you really need to consult your manual.