I'm going to be playing at 1920x1200 and would love to smoothly play at the max settings for almost every game (besides Crysis of course).
So which is honestly the best bang for the buck?
I've never bought an Nvidia card, so a core 216 would be my first.
I've had some good experiences with ATI so far but Sapphire ruined it with their terrible version of the 4870x2.
I'll also probably go crossfire/sli later on.
A gtx 260 (216) OC'd can match and in some cases outperform a stock 4890, and 260s can also OC nicely. However, if you're gaming at that resolution you'd want at least a gtx 275 or 4890 for consistent, fluid performance. Either one is a great selection, just go with what you're comfortable with.