OC'ing CPU causes comp to reboot and reset to defaults.

The first step you test your ram with software memtes86+. only health test ram worry if there is an error this is usually the main cause of overclocking settings can not be stored properly in memory bios!
also check the battery on the motherboard might not be able to support IC bios.

Obviously, your settings are not stable.

This should be your first stop.
Core2 Overclocking Guide
http://www.tomshardware.co.uk/forum/259899-11-core-overclocking-guide

Shadow's Gigabyte motherboard OC guide:
http://www.tomshardware.co.uk/forum/page-245679_11_0.html
It's for an EP35-DS3L.

Go through the guides. Then take your core voltage off Auto and set your memory voltage to factory recommended values. Change the System Memory Multiplier (or whatever your BIOS calls it) from AUTO to 2.00, 2.00B, or 2.00D - whichever you need to set the Memory Frequency to twice the FSB. Then when you increase the FSB, the memory clock will rise in in proportion with it. At an FSB of 333 MHz, your memory clock should be at 667 MHz.