I have two hard drives, one is the C: drive with my windows install and all of my programs, the other is X: with all of my work files. My computer has a bunch of viruses on it and I would like to just wipe the C: drive and reinstall windows on it.
If I do this via the XP install CD's wipe function, do I need to remove my X: drive before doing so or will it not be affected?
Once windows is reinstalled, is there anything that I would need to do to resynch my system with the second X: hard drive?
More about :removing hard drive reinstalling windows
You should not have to remove the storage HDD, but you may want to, so you don't inadvertently install XP on your storage drive.
After you install XP, you can hook-up your storage drive - XP will find it on the next boot, and you can continue using your system as you did before.