Solution
As long as you fill each channel with the same capacity, yes. For mine, I have 2GB sticks in the last slot of each channel and 4GB sticks in the first slot of each channel. It works out to 6GB per channel.

A diagram:

Slot 1 (closest to CPU): 4GB (first slot of channel 1)
Slot 2: 2GB (last slot of channel 1)
Slot 3: 4GB (first slot of channel 2)
Slot 4: 2GB (last slot of channel 2)
As long as you fill each channel with the same capacity, yes. For mine, I have 2GB sticks in the last slot of each channel and 4GB sticks in the first slot of each channel. It works out to 6GB per channel.

A diagram:

Slot 1 (closest to CPU): 4GB (first slot of channel 1)
Slot 2: 2GB (last slot of channel 1)
Slot 3: 4GB (first slot of channel 2)
Slot 4: 2GB (last slot of channel 2)
 
Solution