In addition to contacting Asus to know if it will work, you should also read the FAQ. That motherboard is based on a chipset that's designed to run at 800 MHz. According to Asus it can be overclocked to 1333 MHz, but you'll need to increase the FSB even more if you want to overclock that CPU. You probably won't be able to achieve great results. You'd likely be happier with a used Q6600.